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When to Be Concerned: Abnormal or Severe Reactions While most site reactions are benign, certain signs indicate a need for intervention : Warning Signs: Spreading redness or a halo that increases in size Severe pain that intensifies rather than resolves Hard, painful lump that doesnt go away after several days Pus , drainage, or signs of infection Blistering or skin breakdown Fever , chills, or flu-like symptoms Allergic reaction systemic itching, rash, or anaphylaxis (very rare) If you experience any of the above, stop using the peptide and contact your provider immediately

doi:10.2147/CCID.S286402

Mechanistically, this was explained by dehydration caused by nausea, vomiting and diarrhea (see above)

Cohen O, Snchez-de-la-Torre M, Al-Taie Z, et al

If you are experiencing a medical emergency, call 911 or seek immediate medical attention

In the STEP clinical trials for semaglutide and the SURMOUNT trials for tirzepatide [8,9]